中文摘要：

探讨S-腺苷蛋氨酸（SAM）能否抑制小鼠H22肝癌。通过建立H22小鼠肝癌模型,SAM预防及治疗,检测皮下抑瘤率、皮内肿瘤微血管新成、肺转移等指标对其抗肿瘤作用机理进行部分探讨。结果显示,SAM对H22肿瘤攻击起到有效地保护作用,与PBS阴性对照组相比,预防组和治疗组肿瘤生长缓慢,平均瘤重显著降低（P〈0.01）,抑瘤率达到70%以上;有效地抑制了小鼠皮内模型中的微血管新生（P〈0.01）;同时在一定程度上减少了小鼠的肺转移（P〈0.05）。SAM通过抑制肿瘤血管生长表现出有效的抑制小鼠H22肝癌作用。

英文摘要：

After setting up the animal model of H22,the anti-tumor effects of S-adenosyl-L-methionine（SAM） were investigated by detecting tumor inhibitory rate,tumor-induced angiogenesis and pulmonary metastasis to explore whether SAM can effectively inhibit H22 and to study the mechanism of SAM on anti-tumor.The results of experiment showed that SAM significantly inhibited the growth of H22 in mice.The average tumor weight was significantly lower in the mice treated with SAM,than that in mice injected with PBS（P0.01）.The tumor inhibitory rate is more than 70%.Moreover,SAM attenuated tumor-induced angiogenesis in intradermal tumor model in mice（P0.01）.Meanwhile,SAM can also significantly reduce the number of pulmonary metastases in mice（P0.01）.SAM can effectively suppress the growth of H22 cancer in mice by inhibiting angiogenesis of tumor.