中文摘要：

胰腺癌是预后较差的常见恶性肿瘤之一，其发病率呈逐年上升趋势。据美国临床肿瘤协会统计，全球男性胰腺癌患者病死率居恶性肿瘤的第8位，女性患者居第9位，胰腺癌患者5年生存率始终低于5％。虽然我国胰腺外科水平不断进步，胰腺癌手术切除率有了一定的提高，手术并发症发生率也明显下降，但胰腺癌的治疗效果仍然较差。本文就胰腺癌诊断和治疗的难点问题进行探讨，希望为提高胰腺癌的诊断和治疗水平提供新的思路。

英文摘要：

Pancreatic cancer is an aggressive malignant gastrointestinal tumor, surgical resection offers the only chance of cure. Due to its anatomic and biological characters, early stage pancreatic cancer is usually clinically silent, 80%-85% of patients present with advanced unresectable disease. Further- more, pancreatic cancer responds poorly to most radiochemother- apeutie agents. In this article, we discuss some clinical aspects including early diagnosis, preoperative systemic assessment, surgery and perioperartive adjuvant therapy, and we hope to find the challenges as well as strategies for pancreatic cancer in order to further improve the current level of diagnosis and treatment in China.