中文摘要：

本工作利用天然锑靶，通过^123SB（α，2n）^123I核反应，在控制锑靶厚度为62．2-64．3mg／em。和a粒子能量为26．5MeV的情况下，可以得到11．1TBq／（A·h）以上且核纯度高达98．6％的^123I。利用制备的^123I进行了小分子融合肽拟似物V“CDR-VnFR2-V。CDRs的^123I标记，并对标记物的体外稳定性及在正常小鼠体内的分布进行了初步研究。结果表明，^123I标记VНCDR1-VНFR2-VLCDR2的标记率可达90％以上,^123I标记物在体内不易脱碘且具有较高的体外稳定性。

英文摘要：

^123I with radioactivity of 11.1 TBq/（A· h） and nuclear purity of more than 98. 6% was prepared in the CS-30 cyclotron of Sichuan University via 121Sb（a,2n）^123I nuclear reac- tion by a-energy of 26.5 MeV and using Sb target of 62.2-64.3 mg/cm2. Furthermore, VHCDR,-VHFR2-VLCDR3, a new fusion peptide was labeled with ^23I, and in vitro and in vivo of the labeled peptide was evaluated. The results show that the labeling yield of^123I- VHCDR1-VH FR2-VLCDR3 is more than 90%. The deiodination of^123I labeled VH CDR1- VHFR2-VLCDR3 in vivo is minimal, and ^123 I-VH CDR1-VH FR2-VLCDR3 has a high stability in vitro.