中文摘要：

目的：探讨运动与体重调节密切相关的血清瘦素水平的关系，观察不同运动量对糖尿病大鼠体重、血糖、血清胰岛素和血清瘦素的影响。方法：将实验动物分成6组，分别为正常对照组、正常运动组、糖尿病组、糖尿病小运动量组、糖尿病中运动量组和糖尿病大运动量组。运动组按Ploug方法进行游泳训练。结果：正常运动组大鼠游泳8周后的血清瘦素浓度较运动前显著降低。运动前4组糖尿病组大鼠与正常对照组相比，体重、血清胰岛素和血清瘦素水平显著降低．血糖浓度显著升高。8周后只有糖尿病中运动量组大鼠的每周体重增加数明显回升．血糖浓度较运动前降低35％，血清胰岛素浓度较运动前升高38％，血清瘦素浓度较运动前升高40％。而糖尿病小运动量组和糖尿病大运动量组大鼠运动8周后的上述指标较运动前均无显著性差异。多元相关回归分析．仅提示糖尿病大鼠血清胰岛素是血清瘦素有意义的影响因素。结论：正常生理状态下运动降低血清瘦素水平是机体为维持自身体重稳定和能量平衡的一种适应性反应；而在链脲佐菌素糖尿病状态下，瘦素似乎与胰岛素关系更密切，中等强度运动在降低血糖、改善机体对胰岛素敏感性的同时，似乎也改善了对瘦素的敏感性；运动量不足或运动量过大对糖尿病均无明显治疗效果。

英文摘要：

Objective：To study if exercises can affect serum leptin level that related with weight regulation and observe the influence of different exercises intensity on weight, blood glucose, serum insulin and leptin in STZ diabetic rats. Method：Six experimental groups of rats were investigated： normal controls （NC）, normal exercises （NE）, diabetic group （DG）, diabetic low-intensity exercises group （LEG）, middle-intensity and great-intensity exercises group （MEG and GEG）. Swimming training was administered according to Ploug methods. Result：After 8 weeks swimming, serum leptin concentration of NE markedly decreased. Before swimming, body weight, serum insulin and leptin level of all the STZ diabetic rats were significantly lower than that of NC, and blood glucose were higher. Eight weeks later, only rats of MEG raised an obvious increase in weight lift per week, concentration of blood glucose decreased 35%, serum insulin level increased 38%, serum leptin level increased 40%. However, 8 weeks later the former guidelines in LEG and GEG made no differences with those of pre-exercises. Multiple relation and stepwise regression analysis were applied. It indicated that in diabetic rats only serum insulin was a significant influencing factor of serum leptin. Conclusion：Under normal physiological condition decreased serum leptin level by exercises is an adaptive reaction to maintain stable body weight and balanceable energy, while under STZ diabetic condition, leptin seems to be closely related with insulin. Middle-intensity exercises reduce blood glucose and improve insulin sensitivity, and at the same time, it seems to improve leptin sensitivity. Insufficient exercises or excess exercises have no therapeutic effect on diabetes.