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中文摘要：
目的：探讨糖酵解限速酶6-磷酸果糖激酶-1（PFK1）基因在鼻咽癌活检标本中的表达及意义。方法：采取病例一对照设计，鼻咽癌活检标本取自41例鼻咽癌患者，对照组取自20例鼻咽部慢性炎性患者鼻咽部活检组织，采取实时定量PCR（RT—PCR）检测PFK1mRNA的表达。结果：鼻咽部活检组织中，鼻咽癌组织中PFK1mRNA表达水平明显高于鼻咽部炎性组织；PFK1mRNA在伴有淋巴结转移的鼻咽癌活检组织中表达明显高于无淋巴结转移的鼻咽癌活检组织。结论：PFK1可能是鼻咽癌发生和转移的分子标志之一。
英文摘要：
Objective：The aim of this study is to investigate the expression and clinical significance of 6-phosphofructo-1-kinase in nasopharyngeal carcinoma biopsy samples. Method： Sixty-one biopsy samples were detected, including 41 tissues samples from patients with nasopharyngeal carcinoma and 20 tissues samples from patients with chronic nasopharyngitis as control group. 6-phosphofructo-1-kinase mRNA expression was detected by RT- PCR. Result： It was observed that the expression levels of 6-phosphofructo-1-kinase mRNA in nasopharyngeal carcinoma tissues were higher than in the chronic inflammatory tissues. And the expression levels in patients with lymph node metastasis were higher than without lymph nod metastasis. Conclusion.. 6-phosphofructo-1-kinase may be a marker in occurrence and metastasis of nasopharyngeal carcinoma.
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