设计合成了5-[2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉(5),用IR,UV,1HNMR,MS和元素分析确认其结构.利用DPPH·法和噻唑蓝比色法(MTT法)分别测定了目标产物的抗氧化活性及调控鼠骨髓间质干细胞(MSCs)增殖的作用.结果表明,目标产物有较强的抗氧化活性,在低浓度时对鼠骨髓间质干细胞有促进作用.
5-[2-(8-Hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol (5) was synthesized and characterized by IR, UV, ^1H NMR, MS spectra and elemental analysis. Meanwhile, the stem cell activity and antioxidation activity of the title compound were investigated by the MTT and DPpHo methods. From the result it can be seen that the title compound has strong antioxidation activity and can induce the proliferation of mesenchymal stem cell under a low concentration condition.