<正>To study biomarker of acrylamide (ACR) induced neuropathy,Wistar rats received 20 or 40mg/kg of ACR by ip injection and the levels of light neurofilament (NF-L),middle NF (NF-M),heavy NF (NF-H),β-actin,α-tubulin,and β-tubulin proteins in serum were evaluated using both SDS-PAGE and Western blotting.Compared to controls,NF-L and NF-M decreased,howeverα-tubulin,β-tubulin,and β-actin increased (P<0.01).This result suggested that the change of these cytoskeletal proteins
To study biomarker of acrylamide (ACR) induced neuropathy, Wistar rats received 20 or 40 mg/kg of ACR by ip injection and the levels of light neurofilament (NF-L), middle NF (NF-M), heavy NF (NF-H), β-actin, α-tubulin, and β-tubulin proteins in serum were evaluated using both SDS-PAGE and Western blotting. Compared to controls, NF-L and NF-M decreased,