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Acrylamide Alters Cytoskeletal Protein Level in Rat Serum
  • ISSN号:1002-3127
  • 期刊名称:《毒理学杂志》
  • 时间:0
  • 分类:Q959.837[生物学—动物学] S828.5[农业科学—畜牧学;农业科学—畜牧兽医]
  • 作者机构:[1]School of Public Health, Shandong University, Jinan 250012, Shandong, China, [2]Guangming New District CDC of Shenzhen, Shenzhen 518106, Guangdong, China
  • 相关基金:supported by the National Natural Science Fund of China (No.30872088);Technology Development Plan of Shandong Province(No.2012GSF11854)
中文摘要:

<正>To study biomarker of acrylamide (ACR) induced neuropathy,Wistar rats received 20 or 40mg/kg of ACR by ip injection and the levels of light neurofilament (NF-L),middle NF (NF-M),heavy NF (NF-H),β-actin,α-tubulin,and β-tubulin proteins in serum were evaluated using both SDS-PAGE and Western blotting.Compared to controls,NF-L and NF-M decreased,howeverα-tubulin,β-tubulin,and β-actin increased (P<0.01).This result suggested that the change of these cytoskeletal proteins

英文摘要:

To study biomarker of acrylamide (ACR) induced neuropathy, Wistar rats received 20 or 40 mg/kg of ACR by ip injection and the levels of light neurofilament (NF-L), middle NF (NF-M), heavy NF (NF-H), β-actin, α-tubulin, and β-tubulin proteins in serum were evaluated using both SDS-PAGE and Western blotting. Compared to controls, NF-L and NF-M decreased,

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期刊信息
  • 《毒理学杂志》
  • 中国科技核心期刊
  • 主管单位:北京市卫生和计划生育委员会
  • 主办单位:北京市预防医学研究中心 北京大学医学部公共卫生学院
  • 主编:高星
  • 地址:北京市东城区和平里中街16号
  • 邮编:100013
  • 邮箱:dulixuezz@163.com
  • 电话:010-64407284
  • 国际标准刊号:ISSN:1002-3127
  • 国内统一刊号:ISSN:11-5263/R
  • 邮发代号:82-178
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:4872