中文摘要：

大鼠和仓鼠作为常用的降胆固醇研究模型而被广泛研究。通过喂饲大鼠和仓鼠不同含量膳食胆固醇（0%~0.9%）,对大鼠和仓鼠高胆固醇模型进行比较。结果显示,喂饲胆固醇膳食,仓鼠和大鼠肝脏3-羟基-3甲基-戊二酰CoA还原酶（HMG-CoA-R）的蛋白和基因表达均受到明显的抑制。随着膳食胆固醇添加量的增加,大鼠肝脏低密度脂蛋白受体（LDL-R）表达增加,但是仓鼠和大鼠的LDL-R基因表达均受到抑制。

英文摘要：

Rat and hamster are commonly used rodents to test the efficacy of cholesterol-lowering functional foods. The present study was carried out to compare hamsters with rats as a hypercholesterolemia model which fed one of the four diets containing 0 %-0.9 % cholesterol. Results demonstrated that addition of cholesterol in diet decreased sharply HMG-CoA-R in a dose dependent in rats and so was HMG-CoA-R in hamsters as well as mRNA expression was inhibited in both animals. Hepatic LDL-R in rats was sharply increased in a dependent manner, but it was not seen in hamsters. In contrast, LDL-R mRNA expression in both rats and hamsters was down-regulated.