中文摘要：

P2X3亚单位是嘌呤受体P2X家族成员之一,高度选择性的表达于伤害感受器上,参与炎性痛病理过程。目前炎性痛的动物模型主要包括福尔马林炎性痛模型、弗氏佐剂炎性痛模型、角叉菜胶炎性痛模型、蜜蜂毒炎性痛模型等。不同的炎性痛模型具有不同的病理特征,福尔马林模型的主要特点是双时相的自发痛,由于炎症持续时间的不同,角叉菜胶模型一般用于亚急性的炎症模型,而弗氏佐剂模型和蜜蜂毒模型,以及松节油模型则用于慢性炎性痛模型研究,P2X3受体在其中的表达和功能可能有所不同,本文就外周P2X3受体在不同炎性痛模型中的作用做一综述。

英文摘要：

P2X3 subunit was one of the P2X receptor family members, which highly selective expressd in the nociceptors, and involved in the pathological process of inflammatory pain. Currently, animal inflammatory pain models included formalin inflammatory pain model, Freund＇ s adjuvant inflammatory pain model , the carrageenan inflammatory pain model, bee venom inflammatory pain model, et al. Different inflammatory pain model had different pathological features, the main features of the formalin pain model is double phase of spontaneous pain, due to different duration time of inflammation, carrageenan inflammatory pain model is commonly used in sub acute inflammation model, Freund＇ s adjuvant inflammatory pain model , bee venom inflammatory pain model, and turpentine inflammatory pain model are for chronic inflammatory pain model research, the expression and function of P2X3 may be different. This paper focused on the effects of P2X3 receptors in different inflammatory pain models.