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Rapid determination of pharmaceuticals from multiple therapeutic classes in wastewater by solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry

ISSN号：1673-9108
期刊名称：《环境工程学报》
时间：0
分类：TQ463.4[化学工程—制药化工] O657.72[理学—分析化学;理学—化学]
作者机构：[1]POPs Research Centre, Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China
相关基金：Supported by by the National Science Fund for Distinguished Young Scholars （Grant No. 50625823） and National Natural Science Foundation of China （Grant No. 50538090）

作者： SUI Qian HUANG Jun DENG ShuBo YU Gang[1]

关键词：高效液相色谱, 串联质谱法, 固相萃取, 废水, 药品, 快速测定, 治疗, 污水处理厂, pharmaceuticals, solid phase extraction, tandem mass spectrometry, UPLC, wastewater

中文摘要：

利用极端表演的液体层析(UPLC ) 双人脚踏车团 spectrometry (MS/MS ) 被开发了在废水从 8 个治疗学的班决定 16 药品的一个新分析方法：bezafibrate， clofibric 酸， carbamazepine，咖啡因，氯霉素， diclofenac， gemfibrozil，消炎痛， ketoprofen， mefenamic 酸， metoprolol， nalidixic 酸， N， N-diethyl-meta- 妥路香酰胺， propranolol， sulpiride 和 trimethoprimMS/MS， UPLC 和稳固的阶段抽取(SPE ) 的关键参数被优化。一般来说，目标药品的恢复为废水自河样品是超过 70% 并且 50% 为流入的样品。矩阵抑制的效果，损失被二个内部标准，和可接受的相对恢复成功地在预告的处理以及仪器可变性期间改正被获得。目标混合物是用监视的多重反应(MRM ) 分析的份量上模式，和察觉限制从 0.3 ～ 20 ng/L 。详细研究，在自河废水的矩阵效果也是现在。方法被用于在中国北京从三废水处理植物( WWTP )在废水检测药品，结果证明大多数目标混合物在两个是可检测的流入并且自河与从 20.5～5775.6 ng/L 和 4.6～418.6 ng/L 的吝啬的集中，分别地。增补材料为在 10.1007/s11434-009-0413-y 的这篇文章是可得到的并且为授权的用户是可存取的。

英文摘要：

A new analytical method utilizing ultra-performance liquid chromatography （UPLC） tandem mass spectrometry （MS/MS） has been developed to determine 16 pharmaceuticals from 8 therapeutic classes in wastewater： bezafibrate, clofibric acid, carbamazepine, caffeine, chloramphenicol, diclofenac, gemfibrozil, indomethacin, ketoprofen, mefenamic acid, metoprolol, nalidixic acid, N,N-diethyl-metatoluamide, propranolol, sulpiride and trimethoprim. Key parameters of MS/MS, UPLC and solid phase extraction （SPE） were optimized. In general, recovery of target pharmaceuticals was over 70% for the wastewater effluent samples and 50% for the influent samples. The effects of matrix suppression, loss during the pretreatment as well as instrument variability were successfully corrected by two internal standards, and acceptable relative recovery was obtained. Target compounds were quantitatively analyzed using multiple reaction monitoring （MRM） mode, and the detection limits ranged from 0.3 to 20 ng/L. A detailed study, matrix effect in effluent wastewater was also present. The method was applied to detecting pharmaceuticals in the wastewater from three wastewater treatment plants （WWTPs） in Beijing, China and the results demonstrated that most target compounds were detectable in both the influent and effluent, with the mean concentrations ranging from 20.5 to 5775.6 ng/L and 4.6 to 418.6 ng/L, respectively.