中文摘要：

目的：研究卷柏雌激素有效部位对去势大鼠骨代谢的影响。方法：Wistar雌性大鼠,除假手术组以外均进行去势手术,建立绝经后骨质疏松大鼠模型。术后以卷柏雌激素活性有效部位给药进行干预。给药40 w后,处死大鼠,测定大鼠右股骨骨密度（BMD）和骨生物力学指标;检测血清中碱性磷酸酶（ALP）、钙（Ca）、磷（P）、血清雌二醇（E2）、甲状旁腺素（PTH）、抗酒石酸酸性磷酸酶（TRAP）、骨钙素（BGP）、降钙素（CT）、Ⅰ型前胶原羧基端前肽（PICP）等生化指标。结果：与模型组比较,卷柏有效部位能提高去势大鼠血清中E2与CT水平（P〈0.05）;降低血清中ALP、TRAP、BGP、PTH、PICP水平（P〈0.05）;提高股骨刚度（P〈0.05）;对股骨的骨密度、最大载荷、最大位移、破断位移、最大能量吸收、弹性模量等指标有一定的改善作用,但差异无统计学意义。结论：卷柏雌激素样有效部位对绝经后骨质疏松具有一定的改善作用。

英文摘要：

Objective： To study the effect of estrogen-like effective part of Selaginella tarmariscina on bone metabolism in ovariectomized rats. Methods： Wistar female rats were carried out the castration to remove both ovaries（except the sham group）,in order to establish the rat model of postmenopausal osteoporosis. The estrogen-like effective part of Selaginella tarmariscina was administered after surgery to therapeutic intervention. After 40 weeks of administration,the rats were sacrificed,the right femur bone mineral density（BMD） and bone biomechanical indicators were detected. Serum alkaline phosphatase（ALP）,calcium（Ca）,phosphorus（P）,serum estradiol（E2）,parathyroid hormone（PTH）,tartrate-resistant acid phosphatase（TRAP）,osteocalcin（BGP）,calcitonin（CT）,Ⅰ procollagen carboxy-terminal propeptide（PICP） and other biochemical markers were determined. Results： Compared with the model group,Selaginella tarmariscina effective parts increased the level of serum E2 and CT（P〈0. 05）,reduced serum ALP,TRAP,BGP,PTH and PICP level（P〈0. 05）,improved stiffness（P〈0. 05）,femur bone mineral density,max-load,max-disp,break-disp,energy-absorption and elastic（P〉0. 05）. Conclusion： The estrogen-like effective parts of Selaginella tarmariscina has a certain intervention effect on postmenopausal osteoporosis.