中文摘要：

目的：探讨肺腺癌组织S100A6 mRNA表达与患者临床特征的关系及其意义。方法：用RT-PCR方法检测98例手术后新鲜肺腺癌及癌旁正常肺组织S100A6 mRNA的表达,分析S100A6 mRNA表达与患者临床病理特征及生存预后的关系,ROC曲线法评价S100A6 mRNA表达对肺腺癌的诊断能力。结果：S100A6mRNA在肺腺癌组织中的表达显著高于正常肺组织（P〈0.01）;S100A6 mRNA表达与患者性别和年龄无相关性（P〉0.05）,而与吸烟指数、肿瘤分化、淋巴结转移、远处转移、TNM分期显著相关（P〈0.05）。其中,肿瘤分化、TNM分期和S100A6 mRNA表达是影响肺腺癌患者预后的独立因素。应用ROC曲线法评价S100A6mRNA表达对肺腺癌的诊断能力,其灵敏度、特异度、阳性预测值等指标均明显优于临床上传统肿瘤标志物。结论：S100A6 mRNA在肺腺癌组织中呈过表达,有望成为肺腺癌诊断、治疗评估及预后判断的重要指标。

英文摘要：

Objective：To explore the interrelation and significance between expression of S100A6 mRNA and lung adenocarcinoma clinical and pathological characteristics. Methods： RT -PCR technique was used to detect S100A6 mRNA expression in 98 cases of fresh lung adenocareinoma tissues and their paired adjacent normal lung tissues. The interrelation of S100A6 mRNA expression and clinical and pathological characteristics was analyzed by statistics methods. Receiver operating characteristic （ROC） curve was used to evaluate the diagnosis ability of lung adenocarcinoma. Results ：The expression of S100A6 mRNA was higher in lung adenocarcinoma tissue than that in normal lung tissue （P 〈0.01 ）. The expression of S100A6 mRNA was not related to age and gender（P 〉0.05） ,while was significantly related to smoking index, tumor differentiation, lymph node metastasis, distant metastasis and TNM stage（ P 〈 0.05 ）. Moreover,the tumor differentiation,TNM stage and S100A6 mRNA expression were independent risk factors of lung adenocarcinoma prognosis. S100A6 with high sensitivity, specificity and positive predictive value had an advantage over the traditional tumor markers. Conclusion ： S100A6 mRNA is over - expressed in lung adenocarcinoma tissue and is closely related to the tumor differentiation,TNM stage, etc. It is expected to be as an important marker in diagnosis, treatment and prognosis of lung adenocarcinoma.