中文摘要：

目的探讨氯乙烯接触对工人体内的氧化损伤和肝损伤指标的影响,筛选氯乙烯接触可能的效应生物标志物。方法以160名氯乙烯接触工人为接触组,160名不接触氯乙烯的工人为对照组,测定血清中超氧化物歧化酶（SOD）活力和丙二醛（MDA）含量,以及谷胱甘肽硫转移酶（GST）和乙醇脱氢酶（ADH）活力。结果氯乙烯接触均未对SOD活力、MDA含量和GST活力产生明显影响,氯乙烯接触工人血清ADH活力显著性高于对照组（P〈0.01）。30 000mg～组GST和ADH活力明显高于对照组（P〈0.05）。GST和ADH活力与累积接触剂量存在明显的剂量-反应关系。结论目前氯乙烯接触浓度下氯乙烯对机体的氧化损伤作用不显著。GST和ADH可能是氯乙烯接触的效应生物标志物,但是仍需进一步确认和探讨。

英文摘要：

Objective To investigate the potential oxidative injury,liver lesion induced by vinyl chloride monomer （VCM） and to semen possible effect biomarkers for VCM exposure. Methods 160 workers occupationally exposed to VCM were selected as the exposed group, and 160 workers without VCM exposure as the control group. Activities of serum SOD, MDA, GST, ADH were determined in both groups. Results There was no significant difference between the VCM-exposed workers and those without VCM exposure in the aetivities of SOD, MDA and GST. The activity of ADH of VCM-exposed workers was significantly higher than that of non-exposed workers （P 〈 0. 01 ）. The activities of GST and ADH in individuals with exposure dose over 30 000 mg were higher than those in the control （P 〈 0. 05 ）. There was a dose-response relationship between doses and abnormal rates of GST and ADH. Conclusion The oxidative hazard of VCM exposure is not obviously under the current VCM exposure level. The activities of serum GST and ADH might be used as effect biomarkers to some extent but further confirmation and investigation are still needed.