目的:客观评价中医药治疗抑郁症的临床疗效。方法:以循证医学的原则和方法,对1979至2011年间《中国期刊全文数据》《维普信息资源系统》发表的关于中医药治疗抑郁症临床随机对照试验(RCT)文献采用Jadad质量记分法进行质量评价,并采用Cochrane协作网提供的Revman 4.2.10软件进行Meta分析。结果:共纳入19篇RCT文献,其中Jadad质量记分法14篇得分为2分,4篇为3分,1篇为4分。Meta分析结果提示,中医药干预组与对照组的有效率比较,差异无统计学意义(P〉0.05)。结论:中医药防治抑郁症疗效与西药相当,但因纳入文献研究设计质量较低,中医药防治抑郁症临床治疗效果还需要设计多中心、大样本、随机双盲临床试验进一步验证。
Objective:To evaluate clinical efficacy of traditional Chinese medicine for the treatment of depression.Methods with the principles and methods of evidence-based medicine,"during the period of 1979-2011 Chinese Journal Full-text data" "VIP information resources system" published on traditional Chinese medicine in the treatment of depression clinical randomized controlled trials(RCT) document using Jadad quality score method to evaluate the quality,and carries on the Meta analysis using the Cochrane collaboration′s Revman4.2.10 software.Results:A total of 19 articles of RCT documents,including Jadad quality score 14 points were score of 2,4 points 3 score,1 points were 4.The results of Meta analysis suggest that,Chinese medicine intervention group and the control group in the total efficiency compared with P0.05,no significant difference.Conclusion:The curative effect of traditional Chinese medicine and Western medicine treatment of depression,but into the quality of design document is low,prevention and treatment of TCM clinical depression treatment effect also need large sample,multi-center,randomized double-blind clinical trial design good further verification.