中文摘要：

Toll样受体4（Toll-1ike receptor 4，TLR4）是先天性免疫系统中能够识别病原相关分子模式（pathogen-associated molecular pattem, PAMP）的一种受体，是人们最早发现的TLR，分布于体内各种细胞表面，其信号分子是连接先天和后天免疫的重要桥梁。TLR4不仅可以促进肿瘤发生和转移，而且参与了肿瘤（尤其是炎症相关性肿瘤，如肝癌、结直肠癌、胃癌、宫颈癌等）的免疫逃逸。TLR4可能通过促进肿瘤细胞增殖、抑制肿瘤细胞凋亡及免疫逃逸等机制参与炎症相关性肿瘤的发生发展。

英文摘要：

Toll-like receptor 4 （TLR4） plays a critical role in the innate immune system, acting as pathogen- recognition receptor against microorganisms. TLR4 is the first detected TLR. TLR4 is expressed in a wide variety of cells and tissues, and TLR4 signaling plays an important role in linking the innate immunity and acquired immunity. Body of evidence has showed that TLR4 not only promotes the tumorigenesis and metastasis, but also has effects on tumors＇ immune evasion, especially for inflammation-related cancers such as liver cancer, colorectal cancer, gastric cancer and cervical cancer, etc.. TLR4 could contribute to the tumorigenesis and progression of inflammation-related cancers through promoting tumor cells proliferation, inhibiting tumor cells apoptosis, tumor immune evasion, etc..