中文摘要：

为探索肝素钠对兔颈总动脉损伤后凝血功能的影响,选取雄性新西兰大白兔24只,随机分为空白组和高、中、低三个剂量（1 125、750、375IU/kg）肝素钠组,每组6只。钳夹挤压损伤兔颈总动脉,术后分别肌肉注射不同剂量肝素钠。术后1、3、5、7、9d耳缘静脉采血,分别检测凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB）等凝血参数的变化。结果表明,低剂量肝素钠能纠正血液的高凝状态,而高剂量肝素钠可导致出血倾向。

英文摘要：

To explore the effects of heparin sodium on blood coagulation after carotid artery injury in rabbit,24 male New Zealand white rabbits were randomly dividedin to 4 groups： control,high,medium and low dosages（1 125,750,375 IU/kg）,respectively.Blood vessels were injured by squeezing carotid arteries using two pieces of steel slide.Different dosages of heparin sodium was injected post-operation.Coagulation parameters such as prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrinogen（FIB） were detected 1,3,5,7,9d after heparin sodium administration.Results indicated that low-dose of heparin sodium could retrieve blood hypercoagulable state,while high-dose of heparin sodium had a bleeding tendency.