中文摘要：

目的研究过敏性紫癜（HSP）患儿淋巴细胞亚群的变化及其临床意义。方法收集45例HSP患儿（A组）,其中肾炎型15例（A1组）,非肾炎型30例（A2组）;另选25例健康儿童为对照组（C组）。采用流式细胞术检测外周血中CD3^＋、CD3^＋CD4^＋、CD3^＋CD8^＋、CD3^-CD19^＋、CD3^-CD19^＋CD23^＋以及CD3^-（CD16^＋CD56^＋）的表达水平。结果与C组相比,A组CD3^＋T细胞数量、CD4^＋T细胞数量、CD4/CD8比例、CD3^-（CD16^＋CD56^＋）NK细胞数量均下降（P〈0.05）,而CD3^-CD19^＋B细胞及CD3^-CD19^＋CD23^＋B细胞数量明显增加（P〈0.05）,其中A1组上述指标变化较A2组更为显著（P〈0.05）。结论 HSP患儿T、B和NK细胞数量和功能发生明显变化,表明免疫功能紊乱可能是导致肾脏损伤的重要原因之一。

英文摘要：

Objective To investigate the changes and clinical significance of lymphocyte subsets in children with Henoch-Schonlein purpura（HSP）.Methods Forty-five children with HSP（group A） were divided into two groups of A1（HSP with nephritis,15 cases） and A2（HSP without nephritis,30 cases）.Another 25 healthy children were taken as the controls（group C）.The expression levels of CD3^＋,CD3^＋CD4^＋,CD3^＋CD8^＋,CD3^-CD19^＋,CD3^-CD19^＋CD23^＋ and CD3^-（CD16^＋CD56^＋） in peripheral blood were detected by flow cytometry.Results Compared with group C,the numbers of CD3^＋ T cell,CD4^＋ T cell and CD3^-（CD16^＋CD56^＋） NK cell and the ratio of CD4 to CD8 were all decreased（P〈0.05）,while the numbers of CD3^-CD19^＋ B cell and CD3^-CD19^＋CD23^＋ B cell were significantly increased in group A（P〈0.05）.Moreover,the changes of lymphocyte subsets observed above in group A1 were more obvious than those in group A2（P〈0.05）.Conclusion The numbers and functions of T,B and NK cells are obviously changed in the children with HSP,which indicates that immune disturbance may promote the development of renal injury.