中文摘要：

目的 探讨双相抑郁患者脑白质网络节点介数中心度属性值的改变及其与疾病严重程度的相关性.方法 对17例双相抑郁患者、21例健康对照者进行弥散张量成像扫描,利用解剖学自动标记模板将整个大脑划分为90个区域,对大脑进行确定性纤维追踪,基于复杂理论方法构建脑白质网络.对两组脑网络的节点介数中心度属性值进行双样本t检验,并对差异脑区的属性值与疾病严重程度进行皮尔森相关分析.结果 （1）患者组左侧背外侧额上回（0.69±0.40;t=-3.74,P=0.03）、眶部额下回（0.27±0.19;t=-3.62,P=0.03）、扣带回前部（1.45±0.97;t=-3.53,P=0.03）节点介数中心度属性值较对照组下降,而右侧尾状核（1.89±1.02;t=4.08,P=0.02）节点介数中心度属性值较对照组（1.15±0.35,0.49±0.19,2.69±1.15,0.85±0.51）上升;（2）两组脑网络核心节点分布差异主要位于左侧前额叶以及枕叶;（3）患者组左侧背外侧额上回介数中心度属性值与17项-汉密尔顿抑郁量表总分（r=-0.52;P=0.03）呈负相关.结论 双相抑郁患者左侧前额叶皮质在大脑信息传输活动中的重要性发生下降,而右侧尾状核作为信息集散地的能力上升;同时,患者左侧背外侧额上回在整个脑网络信息处理过程中作用地位的下降与疾病严重程度相关.

英文摘要：

Objective To explore the differences of the betweenness centrality of the brain white matter networks between the bipolar depression （BD） patients and healthy control （HC） subjects,and then analyze its correlation with the severity of the disease.Methods The diffusion tensor imaging data were obtained from 17 BD patients and 21 HC subjects.The whole cerebral cortex was divided into 90 regions by the automated anatomical labeling map.Fiber tracking was performed in the whole cerebral cortex of each subject to reconstruct white matter tracts using the fiber assignment by continuous tracking algorithm.And then the brain white matter networks were constructed using the complex network theory.The nodal betweenness centrality of two groups was examined by two sample t-test and then the correlation between the betweenness centrality of the significant node and the severity of the disease was analyzed by the Pearson correlation analysis.Results The betweenness centrality of BD was significantly decreased in the left superior frontal gyrus （dorsolateral） （0.69±0.40;t=-3.74,P=0.03）,inferior frontal gyrus （orbital part） （0.27±0.19;t=-3.62,P=0.03） and anterior cingulate gyri （1.45±0.97;t=-3.53,P=0.03）,however,that of the right caudate nucleus increased significantly （1.89±1.02;t=4.08,P=0.02） when compared with HC （1.15±0.35,0.49±0.19,2.69± 1.15,0.85±0.51）.The distribution of hub regions in the left frontal and occipital lobes of BD was different from that of HC.Significant negative correlation was found between the betweenness centrality of the left superior frontal gyrus （dorsolateral） and the total scores of 17-item Hamilton Rating Scale for Depression （r=-0.52,P=0.03）.Conclusion The importance of the left prefrontal cortex in the transmission of information activity across the whole brain is decreased,however,that of the right caudate nucleus increased.The reduced importance of the left superior frontal gyrus （dorsolateral） is associated with the severity of the dise