接触性皮炎的发病涉及到表皮角质形成细胞、效应T细胞以及炎症因子的相互作用.除了特异反应性T细胞,不依赖抗原提递细胞提呈的淋巴细胞亚群,也在皮肤变态反应的启动和快速放大中起重要作用.本文就近年来角质形成细胞、免疫细胞及炎症因子在接触性皮炎发病机制中的研究进展做一综述.
Epidermal keratinocyte, effector T cells and cytokines are involved in the pathogenesis of contact dermatitis. Except for the antigen-reactive T cells, the subset of APC-independent lymphocytes may also play a role in the initiation and rapid amplification of the cutaneous allergic reaction. This article summarized the recent progress on the roles of keratinocyte, immunocytes and cytokines in the contact dermatitis.