中文摘要：

外来体（exosomes,EXO）是由细胞内多泡体（multivesicular body,MVB）与细胞膜融合并释放到细胞外的纳米级膜性小囊泡,广泛分布于生物体液中,具有机体耐受特性及诱导归巢能力。外来体可携带蛋白、运送RNA,在肿瘤细胞间的物质传递和信息转导中起到重要作用。近年来,外来体逐渐成为恶性肿瘤研究领域的关注热点,特别是基于外来体的靶向治疗,成为引领肿瘤治疗的新导向。该文就外来体作为生物信息载体在肿瘤中的最新研究作一综述。

英文摘要：

Exosomes are nanometer sized membrane vesicles widely distributed in biological fluids, which are released in the extracellular milieu following the fusion of the extemal membrane of multivesicular body（MVB） with plasma membrane, with the characters of body tolerance and specific homing ability. Exosomes can carry proteins and RNAs and may be involved in intercellular substance transporting and signaling of tumor. In recent years, the role of exosomes in malignant tumor has gradually become hot spots, and especially targeted therapy based on exosomes has become a new orientation in the treatment of cancer. This review will discuss the latest advances of exosomes as the carriers of biological information in the treatment of cancer.