目的:探讨外周血白细胞计数与血压水平的关系。方法:采用横断面研究方法,从门诊及体检人群中随机抽查1136例为研究对象。根据血压水平按JNC-7标准将其分为3组:正常血压组497例(≤120/80 mmHg)、高血压前期组258例(130~139/85~89mmHg)、高血压组371例(≥140/90 mmHg)。通过问卷调查及体检获取一般资料,包括年龄、性别、病史、用药史、家族史等,测量其身高、体重、血压水平,检测外周血白细胞计数、血脂谱、血尿酸、血肌酐及尿素氮等。结果:不同外周血白细胞计数组高血压的发生率不同,随着外周白细胞水平增加其血压水平逐渐增加(P〈0.01)。相关分析显示,无论男性或女性,白细胞计数与收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、体质量指数(BMI)、三酰甘油(TG)相关(P〈0.01)。Logistic多元回归分析显示,在调整了年龄、性别、BMI、腰围、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血肌酐、血尿酸、尿素氮及空腹血糖后,白细胞计数的最高四分位组发生高血压的危险性是白细胞计数最低组的2.1倍(P〈0.01),且高血压的危险性随白细胞计数的增加而增加(P〈0.01)。多元线性回归显示,外周血白细胞计数是MAP、SBP及DBP的独立危险因素(P〈0.01)。结论:外周血白细胞计数与血压水平密切相关,且这种作用独立于其他多重危险因素。
Objective: To explore the relationship between peripheral white blood cell count (PWBC) and blood pressure. Methods:One thousand one hundred and thirty six subjects were enrolled and assigned into 3 groups according to JNC-7, normal blood pressure (4 120/80 mmHg, n = 497), prehypertension(130-139/ 85-89 mmHg, n = 258)and hypertension (≥140/90mmHg, n = 371). The medical history, famlily history and physical situation, including PWBC, cholesterol (CHOL), triglyeride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood sugar (FBS), blood uric acid, creatinine urea nitrogen were measured. Results: The prevalence of hypertension increased with increasing PWBC (P-(0. 01). Correlation analysis showed that PWBC was positively related to mean artery pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI) and TG both in male and female subjects (P%0. 01). However, after adjusting for age, sex, BMI, waist circumference, TC, TG, HDL-C, LDL-C, FBS, blood uric acid, creatinine and urea nitrogen, themultivariable odds ratio (OR) for hypertension comparing quartile 4 of PWBC to lowest 1 was 2.1 (P〈0.01), and multiple regression revealed that PWBC was an independent factor of MAP, SBP and DBP (all P〈0.01 ). Conclusion: The increase of PWI3C is positively correlated to blood pressure, and PWI3C is an independent factor of MAP, SBP and DBP.