中文摘要：

应用Taqman-PCR技术观察磺酰脲类药物受体1基因33外显子（TCC→GCC,S1369A）多态性与格列齐特降糖疗效的关系。发现G等位基因携带者较TT基因型者HbA1c下降显著。

英文摘要：

Taqman-PCR was used to investigate the relationship between exon 33（TCC→GCC, S1369A） polymorphism of sulfonylurea receptor 1 （SUR1）gene and pharmacodynamics of gliclazide. Compared with TT genotype,the patients with GG/GT genotype represented more significant improvement of Hb1Ac level after gliclazide treatment.