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中文摘要：
解旋酶是一种所有生物体都广泛存在的酶，对于几乎所有的核酸代谢都是必需的。Pif1解旋酶家族存在于所有的真核生物，是5’-3’方向依赖ATP的解旋酶。Pif1解旋酶影响端粒、核糖体和线粒体的DNA复制以及冈崎片段的成熟，其影响机制很多是利用其解螺旋活性破坏核蛋白复合体的稳定性。不同的生物Pif1解旋酶功能不同，但其对细胞核和线粒体基因组稳定性的维持是非常重要的。目前已知，酿酒酵母（ScPif1和ScRrm3）、裂殖酵母（SpPfh1）、布氏锥虫（TbPIF1、2、5、8）、小鼠（mPif1）和人类（hPif1）均属于Pif1解旋酶家族，现对上述Pif1解旋酶进行综述。
英文摘要：
Helicases are ubiquitous enzymes found in all organisms necessary for all （ or virtually all ） aspects of nucleic acid metabolism. The Pifl helicase family is a group of 5＇-3＇ directed, ATP-dependent, found in nearly all eukaryotes. Here is to make a review on the discovery, evolution, and currently known facts about these enzymes in Saccharomyces cerevisiae （ ScPifl and ScRrm3 ）, Schizosaccha-romyces pombe （ SpPfhl ）, Trypanosoma brucei（ Tbplel, 2,5, and 8 ）, mice （ mPifl ）, and bumans（ hPifl ）. Pill helicases variously affect telomeric, ribosomal, and mitocbondrial DNA replication, as well as Okazaki fragment matura- tion, and in at least some cases affect these processes by using their belicase activity to disrupt stable nucleo- protein complexes. While the functions of these enzymes vary within and between organisms, it is evident that Pifl family helicases are crucial for both nuclear and mitochondrial genome maintenance.
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