新血管生成在个体发育、创伤愈合等过程中起着至关重要的作用,也是肿瘤生存、转移、复发的组织基础。研究表明,少数极恶性肿瘤存在血管生成(angiogenesis)、血管形成(vasculogenesis)和血管生成拟态(vasculogenic mimicry)等方式,多种血管新生方式与肿瘤的转移、复发等恶性生物行为密切相关。卵巢癌的死亡率在女性生殖道癌瘤中居首位,患者5年生存率长期徘徊在30%左右,最新研究证实,卵巢恶性肿瘤血管生成具有多样性,本文将就卵巢癌不同血管生成方式的研究进展及其与卵巢恶性生物学行为的关系进行综述。
The growth and spread of malignant neoplasms largely depend on angiogenesis. Recent studies demonstrate that a various types of neovascularization including angiogenesis, vasculogenesis and vasculogenic mimicry exist in a few highly aggressive tumors. Ovarian carcinoma is the leading cause of death in gynecologic malignancy. Here, we review the effect of angiogenesis, vasculogenesis and vasculogenic mimicry in development and spread of ovarian carcinoma.