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FUBP1与c-myc在脑胶质瘤中的表达及调控关系
  • ISSN号：1672-4992
  • 期刊名称：现代肿瘤医学
  • 时间：2013
  • 页码：1443-1445
  • 分类：R730[医药卫生—肿瘤;医药卫生—临床医学] R739.41[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构：[1]中国医科大学附属盛京医院神经外科,辽宁沈阳110004, [2]中国医科大学基础医学院神经生物学教研室,辽宁沈阳110001
  • 相关基金：国家自然科学基金资助项目（编号：81172197,81072056,81172408）
  • 相关项目：MicroRNA-330调控SH3GL2基因影响胶质瘤干细胞生物学行为机制的研究
作者： 洪杨|尚超|薛一雪|刘云会|
关键词： 脑胶质瘤, FUBP1, U251细胞, C-MYC, human brain glioma, FUBP1 gene, U251 cell, c-myc
中文摘要：

目的：探讨FUBP1与c-myc在脑胶质瘤组织中的表达及其相关性以及脑胶质瘤细胞中二者之间的调控关系。方法：Real-time PCR检测30例脑胶质瘤及相应癌旁组织中FUBP1和c-myc的表达。设计并合成FUBP1基因特异性的siRNA,转染U251细胞。转染后,Western blot检测FUBP1和c-myc蛋白的表达。结果：与相应癌旁组织相比,胶质瘤组织中FUBP1和c-myc的表达均显著上调,二者呈显著正相关;转染siRNA-FUBP1后FUBP1和c-myc蛋白的表达均显著下调。结论：FUBP1和c-myc在脑胶质瘤中存在表达异常,而且二者的表达存在正相关性,FUBP1在脑胶质瘤细胞中能够上调c-myc的表达。

英文摘要：

Objective：To research the expression and relationship of FUBP1 and c-myc in glioma,and the regulation relationship between them in glioma cells.Methods：Real-time PCR was used to detect FUBP1 and c-myc mRNA in brain glioma and peri-cancerous tissues.siRNA-FUBP1 was transfected to U251 cell,and then the expression of FUBP1 and c-myc protein was dected by Western blot.Results：The expressions of FUBP1 and c-myc mRNA in peri-cancerous tissues were much lower than that in glioma tissues,and there was a positive relationship between FUBP1 and c-myc.After transfection,the expression of FUBP1 and c-myc protein was down-regulated significantly.Conclusion：There are the expression changes of FUBP1 and c-myc gene in brain glioma,and there are positive relation between FUBP1 and c-myc,FUBP1 can up-regulate the expression of c-myc in glioma cells.

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期刊信息
  • 《现代肿瘤医学》
  • 中国科技核心期刊
  • 主管单位:陕西省科学技术协会
  • 主办单位:中国抗癌协会 陕西省抗癌协会 陕西省肿瘤防治研究所 （西安交通大学附属陕西省肿瘤医院）
  • 主编：李树业
  • 地址：西安市雁塔西路309号陕西省肿瘤医院内
  • 邮编：710061
  • 邮箱：sxzlyx@263.net
  • 电话：029-85277356
  • 国际标准刊号：ISSN：1672-4992
  • 国内统一刊号：ISSN：61-1415/R
  • 邮发代号:52-297
  • 获奖情况:
  • 获《CAJ-CD规范》执行优秀期刊奖,陕西省优秀科技期刊一等奖,中国抗癌协会优秀期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,中国中国科技核心期刊
  • 被引量:30005