中文摘要：

目的探究精神病前驱期人群平滑追随过程中的眼动特征。方法纳人60例精神病前驱期被试和性别、年龄及教育年限相匹配的60名正常对照，进行平滑追随任务以检测眼动表现，该实验分为水平直线运动（0．4Hz）、李萨如曲线运动（0．2Hz及0．4Hz）3种任务条件，用韦氏记忆量表第三版空间广度测验评价被试的工作记忆水平，比较两组追随表现，分析其与工作记忆的关系。结果与对照组相比，前驱期组表现出更低的水平方向速度增益[李萨如0．2Hz任务（0．82±0．12）vs．（0．89±0．09），李萨如0．4Hz任务（0．78±0．13）vs．（0．84±0．14）]，更低的竖直方向增益[李萨如0．2Hz任务（0．80±0．14）vs.（0．86±0．12），0．4Hz任务（0．71±0．15）％（0．77±0．16）]及更高的平均位置偏差[李萨如0．2Hz任务（37．00±19．10）vs.（30．45±16．18），李萨如0．4Hz任务（44．18±19．70）vs.（37．61±16．26）1，差异均有统计学意义（P〈0．05）。前驱期被试的竖直（r=0．327，P=0．011）及水平（r=0．361。P=0．005）增益均值与空间广度测验得分之间正相关具有统计学意义。结论精神病前驱期人群存在平滑追随眼动受损，这种受损与他们的工作记忆受损有关。

英文摘要：

Objective To investigate the eye-movement features of smooth pursuit in subjects at clinical high risk for psychosis. Methods sixty subjects at clinical high risk for psychosis and sixty healthy controls were recruited. The smooth pursuit tasks were assessed in both horizontal （0.4 Hz） and Lissajous （0.2 or 0.4 Hz） condition. The Wechsler Memory Scale-third edition and spatial span subtest were used to assess working memory. The difference of the smooth pursuit performance between the two groups and the relationship between smooth pursuit and working memory were ana- lyzed. Results Subjects at clinical high risk for psychosis showed significantly lower Horizontal components for pursuit gain [Lissajous 0.2 Hz task （0.82±0.12） vs. （0.89±0.09）, Lissajous 0.4 Hz task （0.78±0.13） vs. （0.84±0.14）], lower verti- cal components for pursuit gain [Lissajous 0.2 Hz task （0.80±0.14） vs. （0.86±0.12）, Lissajous 0.4 Hz task （0.71±0.15） vs. （0.77±0.16）] and higher mean positional error [Lissajous 0.2 Hz task （37.00±19.10） vs. （30.45± 16.18）, Lissajous 0.4 Hz task （44.18±19.70） vs. （37.61±16.26）] compared to healthy controls （P〈0.05）. There was a significant correlation be- tween pursuit gain and performance on Spatial Span （Horizontal components： r=0.361, P=0.005; vertical components： r= 0.327, P=0.011） in the Subjects at clinical high risk for psychosis. Conclusions Subjects at clinical high risk for psy- chosis showed deficits in smooth pursuit, and the deficits were related to the working memory.