欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
白念珠菌是一种常见的条件致病性真菌。为了在宿主体内复杂的铁离子微环境中定居、生长和繁殖,该菌在长期的进化过程中演化出一系列复杂的铁离子稳态调控网络,包括位于细胞膜表面的铁离子吸收系统和位于细胞内的铁离子储存、转运及利用系统。本文结合课题组研究工作,简要综述近几年关于铁离子吸收、储存及转运机制的研究进展,主要关注细胞内铁离子的储存、转运,尤其是线粒体在胞内铁离子代谢及稳态维持方面的作用。
英文摘要：
Candida albicans is one of the most important opportunistic pathogens. In order to adapt to the various ecological niches of the host, Candida albicans has evolved a variety of sophisticated metabolic strategies to maintain iron homeostasis, including multiple iron acquisition systems that target the cell membranes, and the mechanisms that coordinate intracellular iron trafficking. Here, combined with our study, we review the research advances of iron acquisition, storage and transportation strategies in recent years, focusing on intracellular iron storage and transport, especially the roles of mitochondria in cellular iron metabolism and homeostasis.
同期刊论文项目
同项目期刊论文
Interaction between the vacuole, the mitochondria and oxidative stress response is governed by the t
Spf1 strongly influences calcium homeostasis, hyphal development, biofilm formation and virulence in
Novel role of Candida albicans ferric reductase gene CFL1 iniron acquisition, oxidative stress toler
Candida albicans autophagy, no longer a bystander: Its role in tolerance to ER stress-related antifu
The Ccz1 mediates the autophagic clearance of damaged mitochondria in response to oxidative stress i
Role of TFP1 in vacuolar acidification, oxidative stress and filamentous development in Candida albi
A novel role of the ferric reductase Cfl1 incell wall integrity, adhesion and invasion to host cells
A novel role of the ferric reductase Cfl1 in cell wall integrity, mitochondrial function, and invasi
Inhibitory effect of verapamil on Candida albicans hyphal development, adhesion and gastrointestinal
The type II Ca2+/calmodulin-dependent protein kinases are involved in the regulation of cell wall in
A novel role of the vacuolar calcium channel Yvc1 instress response, morphogenesis and pathogenicity
Aft2, a Novel Transcription Regulator, Is Required for Iron Metabolism, Oxidative Stress, Surface Ad
In vitro activity of verapamil alone and in combination with fluconazole or tunicamycin against Cand
Alkaline stress triggers an immediate calcium fluctuation in Candida albicans mediated by Rim101p an
Roles of Cch1 and Mid1 in morphogenesis, oxidative stress response and virulence in Candida albicans
Ecm7, a regulator of HACS, functions in calcium homeostasis maintenance, oxidative stress response a
Cellular iron homeostasis mediated by the Mrs4-Ccc1-Smf3 pathway is essential for mitochondrial func
Spf1 highly influences Candida albicans calcium homeostasis, hyphal development, biofilm formation a
期刊信息
位置：