目的:探讨培元解毒法对无症状HIV感染者CD4^+计数和血清IL-8、sIL-2R水平的影响。方法:无症状HIV感染者CD4^+计数采用流式细胞术,血清IL-8、sIL-2R水平应用酶联免疫吸附试验法检测,治疗组检测结果与健康对照组比较。结果:治疗组血清IL-8、sIL-2R水平疗前均显著高于健康对照组(P〈0.05)。治疗组疗后CD4^+计数升高,总有效率为78.13%,血清IL-8水平明显下降(P〈0.05),sIL-2R水平略有下降但无统计学意义(P〉0.05),且疗后仍显著高于健康对照组(P〈0.05)。疗前sIL-2R与CD4^+淋巴细胞计数呈负相关。结论:血清IL-8及sIL-2R水平升高代表的异常免疫激活是无症状HIV感染者的病理因素之一,培元解毒法可以在一定程度上降低无症状HIV感染者血清IL-8及sIL-2R水平,是其疗效的可能机制之一。
Objective: Discusses the method of Supplementing primordial qi and getting rid of toxin on asymptomatic HIV Carriers' CD4 + counts and serum IL-8, sIL-2 R level influence. Methods: ELISA method in 32 patients with asymptomatic HIV infection to determine serum levels of IL-8, sIL-2R, and with 22 healthy subjects for comparison. Results : Before treatment there was statistical significance in IL-8 and slL-2R compared with the healthy control group ( P 〈 0.05). After the treatment group therapy CD4+ elevated count, the total effective rate was 78.13% , serum IL-8 level decreased obviously (P 〈 0.05 ) , sIL-2 R level declined slightly but was not statistically significant ( P 〉 0.05 ) , and after treatment is still significantly higher than health in control group (P 〈 0.05 ). Before treatment sIL-2 R and CD4+ T lymphocyte count was negatively correlated. Conclusion: The abnormal immune activation induced by increased serum levels of IL-8 and sIL-2R may be one of the pathological factors in asymptomatic HIV carriers, Fuzheng Paidu tablet can reduce the level of serum IL-8 and sIL-2R in asymptomatic HIV carriers, which may be one of the possible mechanisms.