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中文摘要：
钙离子／钙调蛋白激酶Ⅱ（CaMKⅡ）是一种多功能丝氨酸／苏氨酸蛋白激酶。CaMKⅡ在神经递质、细胞代谢和突触重塑性等方面参与调节，在诸多神经系统疾病中发挥极其重要的作用。CaMKⅡα特异性定位于兴奋性神经元中，一直被认为是研究治疗癫痫的关键所在。体内和体外不同癫痫模型出现caMKⅡ的活性下降。本文从CaMKⅡ的生物学分类、结构与特性以及CaMKⅡ在癫痫中的作用方面进行综述，为深入研究癫痫病理过程及癫痫药物治疗提供新的理论依据。
英文摘要：
Calcium/calmodulin-dependent protein kinase Ⅱ （CaMK Ⅱ ） is a muhifuncfional serine/threonine protein kinase. It plays a vital role in the regulation of , cell metabolism, and synaptic plasticity, as well as in many diseases of the nervous system. As CaMK Ⅱ alpha is specifically located at excitatory neurons ,it has long been regarded as crucial for the treatment of epilepsy. CaMK Ⅱ shows decreased activity after seizures in different in vivo and in vitro models of epilepsy. This article provides a new theoretical basis for fixrther research on the pathological process of epilepsy and its treatment, by exploring several recent experimental studies on CaMK Ⅱ and epilepsy.
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