中文摘要：

目的总结并比较合并与未合并过敏性鼻炎（AR）轻度持续支气管哮喘（简称哮喘）患者临床症状及小气道功能特征。方法采用回顾性分析总结并比较2013年8月至2014年8月门诊初诊轻度持续哮喘患者65例临床症状分布、肺功能指标及呼出气一氧化氮（FeNO）结果，将患者分为AR组与非过敏性鼻炎（NAR）组并比较2组间上述结果的差异。结果患者平均年龄（43．90±13．63）岁，男：女为1：2．4。AR组皮肤点刺试验尘螨阳性比例、血嗜酸粒细胞比例、嗜酸粒细胞绝对值计数、IgE水平较NAR组升高，差异有统计学意义（79．41％ vs 37．50％，χ2=11．19，P〈0．01）；[（7．28±3．06）％VS（4．31±2．07）％，t=2．35，P〈0．05]；[（0．63±0．29）×10^9/L vs（0．42±0．16）×10^9／L，t=2．20，P〈0．05]；[（240．71±68．29）U／ml vs （H9．06±65．39）U/ml，t=2．88，P〈0．05）]；胸闷、气短、全身乏力（活动后明显）、心悸为最常见的临床症状，所占比例分别为98．46％、98．46％、72．31％、66．15％，NAR组心悸症状较AR组高，差异有统计学意义（χ2=5．56，P〈0．05）；AR组咳嗽比例较NAR组高，差异有统计学意义（χ2=5．36，P〈0．05）；AR组吸入支气管扩张剂前FEF2575及FEF75较NAR组降低，差异有统计学意义[（61．07±23．64）％ vs （86．00±28．70）％，t=3．21，P〈0．01]；[（62．7±25．25）％ vs （94．78±31．95）％，χ2=2．32，P〈0．05）]。AR组及NAR组FEN（）值分别为48（7～266）ppb、17．5（5～131）ppb，差异有统计学意义（P=0．0059）。结论轻度持续哮喘患者症状存在异质性；合并AR轻度哮喘患者存在小气道功能受损，其机制与气道嗜酸粒细胞炎症及变应性体质相关。

英文摘要：

Objective To summarize and compare the clinical symptoms and small airway function characteristics of mild persistent asthma patients with and without allergic rhinitis （AR）. Methods A retrospective analysis was performed for 65 cases diagnosed by mild persist asthma during August 2013 to August 2014. The patients were divided into AR group and non-allergic rhinitis group （NAR）. Clinical information including results of skin prick test, blood percentage of eosinophils, absolute value of eosinophils,serum IgE level, symptoms, pulmonary lung function results, fractional exhaled nitric oxide （FENO） were collected and compared between two groups. Results The mean age was （43.90± 13.63） years old with male： female ratio 1 ： 2.4. The percentage of positive skin prick test, blood eosinophil counts,eosinophil absolute value, IgE levels on AR group were higher than NAR group with statistically significant differences [79.41% vs 37.50%, χ2=11. 19, P〈0.01;（7.28±3.06）% vs （4.31±2.07）%, t = 2.35, P〈0.05;（0.63±0.29） × 10^9/L vs （0.42±0.16）× 10^9/L, t =2.20, P 〈0.05; （240.71± 68.29） U/mlvs （119.06±65.39） U/ml, t =2.88, P 〈0.05]. Chest tightness, shortness of breath,malaise after activity, heart palpitation were most four symptoms frequently presented with percentage of 98.46% ,98. 460//00,72.31~//00 and 66.15 ~if0. Heart palpation occurred more frequently in NAR group than in the AR group （ ）2 =5.56, P d0.05）. Cough occurred in NAR group less than in AR group （ 2 =5.36, P %0.05）. The values of FEF25 75 and FEF75 suggesting small airway function were significantly lower in AR group than in NAR group [（61.07±23.64） % vs （86.00±28.70） %, t =3.21, P 〈0.01;（62.7± 25.25） % vs （94.78±31.95） %, t =2.32, P d0.05]. FeNO values in AR grOUp was higher than in NAR group [48 （7~266） ppb vs 17.5 （5~131） ppb, P =0. 005 9]. Conclusions The symptoms complained by mild persistent asthma patients show heterogeneity. The small airway dysfunction ex