中文摘要：

目的比较相同剂量托拉塞米在肾病综合征（NS）患者中分别恒速输液泵静脉滴注2h和静脉注射的疗效，探索托拉塞米治疗Ns水肿的合理用药模式。方法采用2~2自身交叉对照方案，23例住院患者入组并完成了同一剂量托拉塞米的上述两个模式的治疗，洗脱期为48h。结果与静脉注射比较，2h恒速滴注的患者24h尿量、尿氯、尿钠、24h尿钠排泄分数显著升高，尿结合态托拉塞米显著减少，尿量与托拉塞米排泄总量比值显著升高，血药浓度-时间曲线的曲线下面积（AUC）增大（均P〈0．05）。结论在NS患者使用托拉塞米治疗水肿，与常规的静脉注射比较，采用恒速泵延长输液时间至2h，可获得更好的利尿效率。

英文摘要：

Objective To compare the diuretic efficacy of torasemide as a 2-hour continuous infusion and as a bolus injection of equal dose in patients with nephrotic syndrome, and to investigate a preferable administration mode of torasemide for these patients. Methods Twenty-three hospitalized patients were randomized to receive torasemide 20 mg or 40 mg per day by either 2-hour intravenous infusion or bolus injection, and interchanged after 48 hours of washout. Results Patients received torasemide by 2-hour intravenous infusion exhibited significantly higher daily urinary volume, chloride excretion, sodium excretion and fractional excretion of sodium （FENa） within 24 hours than those by bolus injection （P 〈 0.05）. Significantly lower bound-state torasemide excretion, higher ratio of urinary volume to torasemide excretion and a markedly larger area under the curve in the plasma concentration-time profiles were also observed in the infusion group （P 〈 0.05）. Condusion 2-hour continuous infusion delivers a better diuretic effect compared with a bolus injection of equal dose of torasemide in patients with nephrotic syndrome.