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中文摘要：
雌激素参与绝经后骨质疏松的发生、发展过程,其主要通过抑制破骨细胞的活性进而发挥抗骨吸收作用,但是其对破骨细胞的具体作用机制尚未完全阐明.本文主要综述了雌激素对破骨细胞的形态结构、破骨细胞凋亡机制以及破骨前体细胞分化三方面的影响,进而全面阐述雌激素对破骨细胞的作用机制.
英文摘要：
Estrogen is involved in the process of postmenopausal osteoporosis, and the main functional cells are osteoclasts. However, the mechanism of estrogen on the osteoclasts is not yet fully understood. Here we demonstrate the effects of estrogen on osteoclasts in three aspects: morphology and structure, apoptosis of osteoclasts and differentiation of preosteoclasts, which give an overall explanation for effects of estrogen on osteoclasts.
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