中文摘要：

目的：观察翼状胬肉上皮细胞中Pax6的表达情况。方法：应用免疫组织化学染色法检测15例翼状胬肉上皮细胞Pax6、K10、K19以及MUC5AC的表达,并与正常结膜对比。结果：在正常结膜上皮,K19全层表达,Pax6在全层细胞核内表达,K10染色阴性,MUC5AC阳性细胞在上皮表皮层呈单个或簇状散在分布;而翼状胬肉组织Pax6、K19和MUC5AC表达下降甚至阴性表达,且比较差异有统计学意义,而K10在上皮的部分表层细胞中阳性表达。结论：Pax6基因在翼状胬肉上皮细胞表达下调,提示其上皮细胞发生鳞状上皮化生。

英文摘要：

Purpose：To evaluate the expression of Pax6 in pterygia epithelium. Methods：Fifteen patients（15 eyes） with pterygium who underwent simple excision were enrolled in this study.Pax6,K10,K19 and MUC5AC immunostaining were performed in pterygia tissue and normal conjunctiva. Results：A decline or absence of Pax6 expression and K19 keratin and MUC5AC but increased of K10 expression with epidermal differentiation was observed in pterygia epithelium,in comparison with the normal conjunctival tissue. Conclusion：These results indicate that down-regulation of Pax6 is associated with abnormal differentiation of the epithelial cells in pterygium.