中文摘要：

以脯氨酸作为催化剂催化苯并呋喃-2,3-二酮与丙酮的不对称Aldol反应,高选择性地合成了一系列3位含有手性季碳中心的苯并呋喃酮类化合物。

英文摘要：

The 3-substituted 3-hydroxybenzofuran-2-one unit is encountered in a large variety of natural pro-ducts with a wide spectrum of biological activities. Therefore, development of new methodologies to the con-struction of chiral quaternary center at the 3-position of benzofuran-2-one compounds were highly desired. A highly enantioselective Aldol reaction of benzofuran-2,3-ones with ketone catalyzed by N-（2-thiophenesulfo-nyl） prolinamide through enamine activation strategy was developed. As a result, a number of chiral 3-hydro-xyl substituted benzofuran-2-ones derivatives were synthesized with very good yields （ up to 96%） and mode-rate to good enantioselectivities（ up to 91% e. e. ） . This methodology substantially broadens the benzofuranone chemistry and offer functionalized chiral products.