中文摘要：

背景：间充质干细胞是具有多向分化潜能的一类组织干细胞,肿瘤可以诱导间充质干细胞迁移进入肿瘤组织。针对间充质干细胞对肿瘤生长发展的影响目前已经进行了大量的研究。目的：综述间充质干细胞在肿瘤生长发展过程中的作用。方法：应用计算机检索2000-01/2009-06PubMed数据库（网址http：//www.ncbi.nlm.nih.gov/PubMed）相关文章,检索词为＂mesenchymal stem cell,myofibroblast,neoplasms＂,并限定文章语言种类为English。共检索到文献8372篇,37篇文献符合纳入标准。结果与结论：间充质干细胞能够迁移进入肿瘤组织并且可以促进肿瘤的生长发展,这一过程可能与间充质干细胞促进肿瘤间质重构、促进肿瘤血管形成、抑制肿瘤局部机体免疫相关。但是也有一些研究结果表明间充质干细胞可以抑制肿瘤生长。因此进一步加深间充质干细胞与肿瘤关系的研究可能会增加人们对肿瘤发病机制的理解。

英文摘要：

BACKGROUND：Mesenchymal stem cells are the cells with the potential of multiple-directional differentiation.Tumor can induce migration of mesenchymal stem cells into tumor tissue.There are many studies concerning the influence of mesechymal stem cells on tumor growth and development.OBJECTIVE：To review the influence of mesechymal stem cells on tumor growth and development.METHODS：The PubMed database（http：//www.ncbi.nlm.nih.gov/PubMed）（2000-01/2009-06） was searched online.The Key words were ＂mesenchymal stem cell,myofibroblast,neoplasms＂.The language was limited as English.Totally 8 372 papers were included.Finally,37 articles were accorded with inclusion criteria.RESULTS AND CONCLUSION：Mesenchymal stem cells can migrate into tumor tissue and accelerate tumor development under the induction of tumor tissue,which may be related to the influence of mesenchymal stem cells on tumor stroma remodeling,local immune status and vascular formation.However,some studies have suggested that mesenchymal stem cells suppress tumor growth.Therefore,further studies addressing the relationship between mesenchymal stem cells and tumor development are necessary,which may strengthen our recognition to the mechanism of tumor development.