中文摘要：

目的分析代谢综合征（MS）各成分对老年人良性前列腺增生（BPH）临床病程进展的影响因素。方法将155例BPH患者根据是否患MS分为单纯BPH组（n=86）和BPH合并MS组（n=69），分析2组各代谢指标和BPH指标的差异；分别以BPH患者的前列腺体积（TPV）、残余尿量、最大尿流率（Qmax）、国际前列腺症状评分（IPSS）、血清前列腺特异性抗原（PSA）、前列腺年增长率为因变量，以MS各成分为自变量，进行多元线性回归分析。结果单纯BPH组与BPH合并MS组比较，BPH患者的病程进展观察指标PSA、TPV、Qmax、IPSS、前列腺年增长率等的差异均有统计学意义（P〈0．05）。多元线性回归显示，与TPV正相关的成分为空腹血糖、胰岛素抵抗指数、腰围（P〈0．05）；与残余尿量正相关的成分为胰岛素抵抗指数（P〈0．05）；与Qmax负相关的成分为胰岛素抵抗指数（P〈0．01）；与IPSS评分正相关的成分为体重指数（P〈0．叭）、空腹血糖、腰围（P〈0．05）；与PSA正相关的成分为空腹血糖（P〈0．05），与前列腺年增长率正相关的成分为空腹血糖、空腹胰岛素（P〈0．05）。结论针对MS中的不同成分，各个BPH临床进展指标各有其独立的影响因素，针对BPH患者不同的临床指标，应采取不同的治疗方案。

英文摘要：

Objective To explore the chnical progression factors for the metabohc syndrome （MS） on elderly benign prostatic hyperplasia （BPH）. Methods A total of 155 elderly BPH were divided into two groups：simple BPH （n =86） and BPH with MS （n =69） groups,the differences of the metabolic and BPH index between two groups were compared. By multiple linear regression,the effects and correlation of prostate volume （ TPV ）, residual urine volume, Qmax, international prostate symptom score （ IPSS ）, prostate-specific antigen （ PSA ）, and an- nual prostate growth rate with various components of MS were analyzed. Results There were statistical differences （P 〈 0.05 ） on TPV, Qmax, IPSS, PSA, and annual prostate growth rate between BPH and BPH with MS groups. The multiple linear regression showed that the TPV has a significantly positive correlation with FBG and HOMA-IR. Residual urine volume showed a significantly positive correlation with HOMA-IR. Qmax has a significantly negative correlation with HOMA-IR. IPSS has a significantly positive correlation with BMI, FBG and waist circumference. PSA has a significantly positive correlation with FBG. Annual prostate growth rate has a significantly positive correlation with FBG and FINS. Conclusion MS has evident effects on the development of BPH.