中文摘要：

某些 pseudogenes 可以由为 miRNAs 竞争调整他们的编码蛋白质的表亲并且在癌症起一个活跃生物作用。然而，很少研究与癌症预后在 pseudogenes 集中了于基因变化的协会。我们在癌症相关的 pseudogenes 选择了六潜在地功能的单个核苷酸多型性(SNP ) ，并且执行了盒子唯一的研究没有外科的治疗，在 331 个 HBV 积极的 HCC 病人估计在那些 SNP 和 hepatocellular 癌(HCC ) 的预后之间的协会。比例的危险建模的木头等级测试和考克斯被用于幸存分析。我们发现在 E2F3P1 的 rs9909601 的 A 等位基因显著地与 G 等位基因相比与更好的预后被联系[调整危险比率(HR ) ； = ；0.69， 95% 信心间隔(CI ) ； = ；0.56-0.86， P  ； = ；0.001 ] 。另外，没有化疗和 transcatheter，这保护的效果为病人是更占优势的肝的动脉的 chemoembolization (不作声) 治疗。有趣地，我们也检测了在 rs9909601 和化疗的遗传型之间的一个统计上重要的趋于增加的相互作用或不作声 HCC 幸存上的地位(为趋于增加的相互作用 < 的 P；0.001 ) 。这些调查结果显示在 pseudogene E2F3P1 的 rs9909601 可以是为用汉语的 HCC 预后的一个基因标记。

英文摘要：

Certain pseudogenes may regulate their protein-coding cousins by competing for miRNAs and play an active biological role in cancer. However, few studies have focused on the association of genetic variations in pseudogenes with cancer prognosis. We selected six potentially functional single nucleotide polymorphisms （SNPs） in cancerrelated pseudogenes, and performed a case-only study to assess the association between those SNPs and the prognosis of hepatocellular carcinoma （HCC） in 331 HBV-positive HCC patients without surgical treatment. Log-rank test and Cox proportional hazard models were used for survival analysis. We found that the A allele of rs9909601 in E2F3P1 was significantly associated with a better prognosis compared with the G allele [adjusted hazard ratio （HR） = 0.69, 95% confidence interval （CI） = 0.56-0.86, P = 0.001]. Additionally, this protective effect was more predominant for patients without chemotherapy and transcatheter hepatic arterial chemoembolization （TACE） treatment. Interestingly, we also detected a statistically significant multiplicative interaction between genotypes of rs9909601 and chemotherapy or TACE status on HCC survival （P for multiplicative interaction 〈 0.001）. These findings indicate that rs9909601 in the pseudogene E2F3P1 may be a genetic marker for HCC prognosis in Chinese.