背景基因混合指在种以内在二之间杂交或更以前孤立的人口的过程或后果。比作象变化,基因飘移,和自然选择那样的许多另外的进化驱动力,基因混合是为塑造人口 genomic 的快机制差异。特别地,混合导致在不同人口被修理了的基因变体的再结合,它有许多进化、医药的含意。不管多么的结果,精确地重建是挑战性的人口混合历史并且人口混合动力学理解。在这评论,我们为祖先推理和混合分析提供模型,方法,和工具的概述。许多方法和工具为混合分析使用了的结论原来被开发分析人的数据,而是这些方法能直接也被使用或稍微修改了也学习非人类的种类。
Background: Genetic admixture refers to the process or consequence of interbreeding between two or more previously isolated populations within a species. Compared to many other evolutionary driving forces such as mutations, genetic drift, and natural selection, genetic admixture is a quick mechanism for shaping population genomie diversity. In particular, admixture results in "recombination" of genetic variants that have been fixed in different populations, which has many evolutionary and medical implications. Results: However, it is challenging to accurately reconstruct population admixture history and to understand of population admixture dynamics. In this review, we provide an overview of models, methods, and tools for ancestry inference and admixture analysis. Conclusions: Many methods and tools used for admixture analysis were originally developed to analyze human data, but these methods can also be directly applied and/or slightly modified to study non-human species as well.