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Models, methods and tools for ancestry inference and admixture analysis
  • ISSN号:0253-9772
  • 期刊名称:《遗传》
  • 时间:0
  • 分类:Q959.838[生物学—动物学] TG7[金属学及工艺—刀具与模具]
  • 作者机构:[1]CAS Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, CAS, Shanghai 200031, China, [2]University of Chinese Academy of Sciences, Beijing 100049, China, [3]Department of Mathematics, School of Science, Beijing Jiaotong University, Beijing 100044, China, [4]School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China, [5]Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China
  • 相关基金:S.X. acknowledges financial support from the National Natural Science Foundation of China (NSFC) grant (Nos. 91331204 and 31711530221), the Strategic Priority Research Program (No. XDBI3040100) and Key Research Program of Frontier Sciences (No. QYZDJ-SSW-SYS009) of the Chinese Academy of Sciences (CAS), the National Science Fund for Distinguished Young Scholars (No. 31525014), and the Program of Shanghai Academic Research Leader (No. 16XD1404700); S.X. is Max-Planck Independent Research Group Leader and member of CAS Youth Innovation Promotion Association. S.X. also gratefully acknowledges the support of the National Program for Top-notch Young Innovative Talents of The "Wanren Jihua" Project. We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuseript. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
中文摘要:

背景基因混合指在种以内在二之间杂交或更以前孤立的人口的过程或后果。比作象变化,基因飘移,和自然选择那样的许多另外的进化驱动力,基因混合是为塑造人口 genomic 的快机制差异。特别地,混合导致在不同人口被修理了的基因变体的再结合,它有许多进化、医药的含意。不管多么的结果,精确地重建是挑战性的人口混合历史并且人口混合动力学理解。在这评论,我们为祖先推理和混合分析提供模型,方法,和工具的概述。许多方法和工具为混合分析使用了的结论原来被开发分析人的数据,而是这些方法能直接也被使用或稍微修改了也学习非人类的种类。

英文摘要:

Background: Genetic admixture refers to the process or consequence of interbreeding between two or more previously isolated populations within a species. Compared to many other evolutionary driving forces such as mutations, genetic drift, and natural selection, genetic admixture is a quick mechanism for shaping population genomie diversity. In particular, admixture results in "recombination" of genetic variants that have been fixed in different populations, which has many evolutionary and medical implications. Results: However, it is challenging to accurately reconstruct population admixture history and to understand of population admixture dynamics. In this review, we provide an overview of models, methods, and tools for ancestry inference and admixture analysis. Conclusions: Many methods and tools used for admixture analysis were originally developed to analyze human data, but these methods can also be directly applied and/or slightly modified to study non-human species as well.

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期刊信息
  • 《遗传》
  • 中国科技核心期刊
  • 主管单位:中国科学院
  • 主办单位:中国遗传学会
  • 主编:张永清
  • 地址:北京朝阳区北辰西路1号院中国科学院遗传发育所
  • 邮编:100101
  • 邮箱:yczz@genetics.ac.cn
  • 电话:010-64807669
  • 国际标准刊号:ISSN:0253-9772
  • 国内统一刊号:ISSN:11-1913/R
  • 邮发代号:2-810
  • 获奖情况:
  • 中国自然科学核心期刊,《CAJ-CD》执行优秀奖,2008年12月获“中国精品科技期刊”证书和北京市印...
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  • 被引量:23270