中文摘要：

目的探讨WASP家族富含脯氨酸同源蛋白1（WASP-familyverprolin—homologousprotein1，WAVE!）及基质金属蛋白酶-2（matrixmetalloproteinases-2，MMP-2）和基质金属蛋白酶_9（MMP-9）在卵巢癌的表达及临床意义。方法采用免疫组化SABC三步法检测47例卵巢癌、30例卵巢良性肿瘤和21例正常卵巢组织中WAVEl、MMP-2、MMP-9的表达，并对卵巢癌组织WAVEl与MMP-2、MMP-9的表达进行相关性分析。结果（1）WAVEl、MMP-2及MMP-9在卵巢癌中的表达均高于在正常卵巢组织及卵巢良性组织中的表达，差异有统计学意义（P〈0．05）；Spearman相关分析显示，WAVEl和MMP．2、MMP-9两两表达成正相关（r=0．773，r=0．664，P〈0．05）。（2）WAVEl的表达与卵巢癌的临床分期、组织分化及Ca-125水平有关（P〈0．05），与年龄、肿瘤的直径无关（P〉0．05）。MMP-2、MMPO表达与卵巢癌的临床分期有关（P〈0．05），与年龄、组织分化、Ca-125水平及肿瘤直径无关（P〉0．05）。结论WAVEl和MMP-2、MMP-9在卵巢癌中呈现高表达，早期联合筛查WAVEl和MMP-2、MMP-9指标对卵巢癌病情演变和预后评估有着重要的临床意义。

英文摘要：

Objective To investigate the expression and clinical significance of WASP-family verprolin-homologous protein 1 （WAVE1）, matrix metalloproteinase-2 （MMP-2） and -9 （MMP-9） in ovarian cancer. Methods The expression of WAVE1, MMP-2 and MMP-9 in 47 cases of ovarian cancer tissues, 30 cases of benign ovarian tumor tissues and 21 cases of normal ovarian tissues were detected by SABC immunohis- tochemical method. The correlation among WAVE1, MMP-2 and MMP-9 was analyzed. Results The positive expression rates of WAVEI, MMP-2 and MMP-9 in ovarian cancer tissues were significantly higher than those in benign ovarian tumor tissues and normal ovarian tissues （ P 〈 0.05 ）. Spearman correlation analysis showed that positive correlation were found among WAVE1, MMP-2 and MMP-9 in ovarian cancer （P 〈 0.05 ）. The expres- sion of WAVE1 was correlated with the clinical stage, histological differentiation and Ca-125 level （P 〈0.05） rather than the age and the size of tumor （P 〉 0.05 ） , while the expression of MMP-2 and MMP-9 was correla- ted with the clinical stage of ovarian cancer （P 〈 0.05 ） rather than the age, histological differentiation, Ca-125 level and the size of tumor （P 〉 0.05）. Conclusion WAVE1, MMP-2 and MMP-9 are highly expressed in ovarian cancer tissues. Combined screening of WAVE1, MMP-2 and MMP-9 at early stage may have crucial clinical significance for evaluation of progress and prognosis of ovarian cancer.