中文摘要：

为了研究Caliban的肿瘤抑制机制,通过酵母双杂交的方法筛选得到了4个新的Caliban相互作用蛋白：Bip2、Uba2、RpS27A和CG7182.它们的功能涉及转录调节、肿瘤抑制和泛素化修饰等过程.通过免疫共沉淀证实了Bip2与Caliban在体外结合,并发现在果蝇体内过表达Bip2可以抑制p53的转录.这些结果为研究Caliban的肿瘤抑制功能提供了基础.

英文摘要：

Caliban is a tumor suppressor.To understand its inherent mechanisms,we screened Caliban interacting proteins using the yeast two-hybrid system.We found four new Caliban interacting proteins,Bip2,Uba2,RpS27A,and CG7182.Moreover,over-expression of transcriptional factor Bip2 suppresses transcription of p53.The tumor suppression function of p53 could be regulated through new mechanisms involving Bip2 and Caliban.