中文摘要：

目的采用meta分析方法研究大豆异黄酮摄入对骨丢失影响。方法搜索MEDLINE、中国期刊网等中外数据库,收集了考察大豆异黄酮摄入与尿脱氧吡啶酚（Dpyr）、血清骨特异性碱性磷酸酶（BAP）、脊椎骨骨密度（SBMD）相关的随机对照研究,并对符合纳入标准的研究进行了meta分析。结果纳入18篇研究,978个研究对象。与对照组相比,大豆异黄酮组尿Dpyr的浓度显著降低,其效应值为-2.08nmol/mmol（95%CI：-3.82～0.34）;血清BAP的浓度显著升高了1.48μg/L（95%CI：0.22,2.75）,大豆异黄酮摄入组SBMD显著增加了20.6mg/cm2（95%CI：4.5～36.6）。当大豆异黄酮摄入量大于90mg/d或持续时间6个月时,对SBMD的影响效应值分别为28.5mg/cm2（95%CI：8.4～48.6）和27mg/cm^2（95%CI：8.3～45.8）。结论大豆异黄酮干预能显著地抑制骨吸收和刺激骨形成,从而改善骨质量,防止妇女骨质疏松的发生。

英文摘要：

Objective To clarify the effects of soy isoflavone intake on bone loss, meta-analysis of randomized controlled trials （RCTs） was performed. Methods RCTs that observed the effects of soy isoflavone intake on urinary deoxypyridinoline （Dpyr）, serum bone-specific alkaline phosphatase （BAP）, and spine bone mineral density （SBMD） were searched by MEDLINE, CNKI, and so on. Meta-analysis for the RCTs selected in the analysis was performed. Results Eighteen studies with a total of 978 subjects were selected for the analysis. The urinary Dpyr concentration in subjects who consumed isoflavones significantly decreased by - 2.08nmol/mmol （95 % CI ： - 3.82 - 0. 34） in comparison to that in subjects who did not consume isoflavones. However, isoflavone intake significantly increased serum BAP by 1.48μg/L （95 % CI： 0. 22- 2.75）. The SBMD in subjects who consumed isoflavones increased significantly by 20.6rag/ cm^2 （95% CI：4.5 - 36.6）. Subjects who consumed isoflavone more than 90mg/day and or 6 months increased SBMD as 28.Smg/cm^2（95% CI：8.4 - 48,6） and 27mg/cm^2 （95% CI：8.3 - 45.8）, respectively. Conclusion It was suggested that the bone loss in menopausal women attenuated by isoflavone intervention could be associated with inhibition of bone resorption and stimulation of bone formation.