中文摘要：

真核细胞的染色质组装是组蛋白和DNA有序地形成核小体和染色质的过程．通过调节DNA的开放或折叠状态，染色质组装不但影响遗传信息的编码和存储，也决定了遗传信息的提取和解读．作为染色质组装的重要调控因子，组蛋白变体和组蛋白伴侣在与DNA相关的生命活动进程中发挥着至关重要的作用．本文综述了组蛋白变体H2A．Z以及CENP-A进行染色质组装的研究进展，并着重讨论了组蛋白变体和组蛋白伴侣在染色质组装中的重要作用．

英文摘要：

Chromatin assembly in eukaryote is a well-organized process in which DNA and histone are hierarchically packaged into the nucleosome and chromatin. The assembly and disassembly of chromatin decode the genetic information stored within the chromatin. Histone variant and histone chaperone are major players in regulating the chromatin assembly and virtually involve in all DNA-based processes. In this review, we discuss the recent findings that provide insights into the assembly mechanism of histone variant H2A.Z and CENP-A, and highlight the important roleshistone chaperones play in this process.