中文摘要：

背景：BAFF， B 房间致活因子，是肿瘤坏死因素(TNF ) 的一个成员绑在 BCMA， TACI，和 BAFF-R 的 ligand 家庭。以前的研究证明了 TNF 家庭的成员在人的胎盘的滋养层房间，而是涉及人的蜕膜和在正常怀孕和流产之间的 BAFF 的微分表示的 BAFF 的表示模式被检测仍然不完全地被记录或未知。这研究被设计在正常早怀孕的女人和周期性的自发流产(RSA ) 的滋养层和蜕膜调查 BAFF 和 BAFF-R 的表示病人。方法：有 RSA 和 45 个正常怀孕女人的 45 个病人在这研究被包括。由反向的 transcriptase 聚合酶链反应(RT-PCR ) ，西方的弄污和免疫组织化学的实验，我们在正常早怀孕的女人和 RSA 病人的属母的, 母的, 母性胎儿的接口探索了 BAFF 和 BAFF-R 的表示。结果：由 RT-PCR 并且西方的弄污的分析表明 BAFF 在所有样品的滋养层和蜕膜被检测，并且表示水平比在一样的妊娠的星期下面的周期性的自发流产病人的在正常早怀孕的女人(P【0.05 ) 的纸巾是更高的。为 BAFF-R 的消息是不在的。Immunohistochemical 实验证明 BAFF 的那表情是房间特定的它在滋养层并且到在蜕膜的基质房间对覆有一层绒毛的细胞滋养层和合胞体滋养层房间局部性。而 BAFF 在正常早怀孕的女人的滋养层和蜕膜上是突出的，它在 RSA 病人的纸巾被减少。结论：BAFF 可能驾驶母亲的白血球离开有害有免疫力的回答并且向有利的并且为成功的怀孕起一个潜在地重要的作用。

英文摘要：

Background BAFF, the B cell activation factor, is a member of the tumor necrosis factor （TNF） ligand family that binds to BCMA, TACI, and BAFF-R. Previous studies have shown that members of the TNF family are detected in human placental trophoblast cells, but the expression patterns of BAFF involved in human decidua and the differential expression of BAFF between normal pregnancy and miscarriage are still incompletely documented or unknown. This study was designed to investigate the expression of BAFF and BAFF-R in the trophoblast and decidua of normal early pregnant women and recurrent spontaneous abortion （RSA） patients. Methods Forty-five patients with RSA and 45 normal pregnant women were included in this study. By reverse transcriptase-polymerase chain reaction （RT-PCR）, Western blotting and immunohistochemical experiments, we explored the expression of BAFF and BAFF-R in the maternal-fetal interface of normal early pregnant women and RSA patients. Results Analysis by RT-PCR and Western blotting revealed that BAFF was detected in both trophoblast and decidua of all the samples, and the expression level was higher in the tissues of normal early pregnant women （P〈0.05） than that of recurrent spontaneous abortion patients under the same gestational weeks. Messages for BAFF-R were absent. Immunohistochemical experiments showed that expression of BAFF was cell-specific which was localized to villous cytotrophoblast and syncytiotrophoblast cells in trophoblast and to stromal cells in decidua. Whereas BAFF was prominent on the trophoblast and decidua of normal early pregnant women, it was decreased in the tissues of RSA patients. Conclusions BAFF might steer maternal leukocytes away from a harmful immune response and toward a favorable one and play a potentially vital role for successful pregnancy.