中文摘要：

本文通过荧光滴定、紫外可见吸收滴定、紫外熔点实验以及CD光谱研究了三联吡啶衍生物L1-L3及其Pt（Ⅱ）配合物1-3和人端粒i-motif DNA的相互作用。结果表明：配体和配合物均能与i-motif DNA相互作用,结合常数约为105M-1,而且配合物的亲和作用强于配体。配合物的结合导致i-motif DNA的熔点温度降低并对其构象产生扰动。

英文摘要：

The interactions of terpyridine derivatives（L1-L3）and their Pt（Ⅱ）complexes（1-3）with human telomeric i-motif DNA were studied by UV-visible absorption titration,fluorescence titration,UV melting,and CD spectroscopy. The results show that these compounds can bind to i-motif DNA,and the affinity potential of complexes to i-motif DNA is larger than ligands,with the binding constants（Kb）of 3. 20（3. 80（105and 1. 20（1. 43（105M-1,respectively. UV-melting and CD spectral results indicate that the bind-ing of complex destabilizes the structure of i-motif DNA,while the binding of ligands fails to change the conformation and the melt-ing temperature of DNA.