脑卒中是当前严重危害人类健康的疾病之一,包括缺血性卒中和出血性卒中两大类。有些药物可导致血黏度增高,具有潜在缺血性卒中的风险;而作为治疗心脑血管疾病的重要药物,抗血小板和抗凝药物本身亦增加了患者颅内出血及死亡的风险。据此,本文提出药物相关性卒中的概念,并探讨患者在使用相关药物期间的颅内出血风险及需接受神经外科手术时的围术期处理方案,旨在引起临床医师对药物相关性卒中的重视,为临床治疗提供指导和依据。
Stroke classified into ischemic and hemorrhagic subtypes, is among the most devastating diseases for human being. Certain drugs could increase the blood viscosity, thereby increasing the potential risk of ischemia. Anti-platelet and anti- coagulation drugs, as the treatment of first choice, increase the risk of intracranial hemorrhage and death. Here, we are the first to propose the concept of drug-related stroke, and discuss the treatment strategy for patients who are complicated with intracranial hemorrhage or plan to receive neurosurgical operation during either anti- platelet or anti-coagulation medication. We hope to arouse the attention for drug related stroke among the clinicians and offer recommendation for clinical intervention.