中文摘要：

背景 Progranulin 是原来净化从的最新发现的 88-kDa glycoprotein 高度 tumorigenic 老鼠导出 teratoma 的房间线 PC。它的表示密切与几癌症的发展和转移被相关。然而，当在乳癌的变形风险和预后的一个新标记还没被学习了，没有 immunohistochemical 证据当前在 progranulin 的胸癌活体检视，和角色与 clinicopathologic 特征存在到相互关联 progranulin 表示。这研究的目的是在有肿瘤 angiogenesis 的胸癌和它的关联调查 clinicopathologic 和 progranulin 表示的预示的含意。方法 Progranulin 表示从胸 fibroadenomas 与乳癌和 20 件织物样品从病人在 183 个外科的标本 immunohistochemically 被决定。肿瘤 angiogenesis 相关的 biomarker，脉管的 endothelial 生长因素是 assayed， microvessel 密度被在用 endoglin 抗体标记的肿瘤纸巾数脉管的 endothelial 房间估计。在 progranulin 表示和 clinicopathologic 数据之间的关系是 analyzed.Results Progranulin 蛋白质是在乳癌的 overexpressed。progranulin 表示的水平显著地与肿瘤尺寸(P=0.004 ) 被相关，淋巴节点转移(P 0.001 ) 和 TNM 阶段(P 0.001 ) 。高 progranulin 表示与更高的肿瘤 angiogenesis 被联系，由增加的脉管的 endothelial 生长因素表示( P0.001 )和更高的 microvessel 密度( P=0.002 ) .Conclusion Progranulin 思考了可以是为估计乳癌的转移和预后的一个珍贵标记，并且能为新联合政体向基础提供 antiangiogenic 活动。

英文摘要：

Background Progranulin is a newly discovered 88-kDa glycoprotein originally purified from the highly tumorigenic mouse teratoma-derived cell line PC. Its expression is closely correlated with the development and metastasis of several cancers. However, no immunohistochemical evidence currently exists to correlate progranulin expression with clinicopathologic features in breast carcinoma biopsies, and the role of progranulin as a new marker of metastatic risk and prognosis in breast cancer has not yet been studied. The aim of this study was to investigate the clinicopathologic and prognostic implications of progranulin expression in breast carcinoma and its correlation with tumor angiogenesis. Methods Progranulin expression was determined immunohistochemically in 183 surgical specimens from patients with breast cancer and 20 tissue samples from breast fibroadenomas. The tumor angiogenesis-related biomarker, vascular endothelial growth factor was assayed and microvessel density was assessed by counting vascular endothelial cells in tumor tissues labeled with endoglin antibody. The relationship between progranulin expression and the clinicopathologic data were analyzed. Results Progranulin proteins were overexpressed in breast cancer. The level of progranulin expression was significantly correlated with tumor size （P=0.004）, lymph node metastasis （P 〈0.001） and TNM staging （P 〈0.001）. High progranulin expression was associated with higher tumor angiogenesis, reflected by increased vascular endothelial growth factor expression （P〈0.001） and higher microvessel density （P=0.002）. Conclusion Progranulin may be a valuable marker for assessing the metastasis and prognosis of breast cancer, and could provide the basis for new combination regimens with antiangiogenic activity.