中文摘要：

目的：探讨表皮生长因子（EGF）及其受体（EGFR）在鼻息肉上皮中的表达及其意义。方法收集鼻息肉标本25例，正常下鼻甲黏膜组织10例，采用免疫组化及实时荧光定量 PCR 技术，观察 EGF 与 EGFR 在鼻息肉和正常下鼻甲黏膜组织中的表达情况。结果与正常下鼻甲黏膜组织相比，EGF 及 EGFR 的 mRNA 水平在鼻息肉组织中的表达下降。在免疫组化染色中，EGF 及 EGFR 主要表达在上皮的基底层细胞，而且在鼻息肉中的表达下降。结论EGF 及 EGFR 在正常鼻黏膜组织上皮的发生与修复中有着重要的作用。EGF 及 EGFR 在鼻息肉中蛋白水平与 mRNA 水平表达的下降表明在鼻息肉中上皮修复功能的下调或缺失可能导致或促进鼻息肉的发生。

英文摘要：

Objective To investigate the expressions of epidermal growth factor （EGF）and epidermal growth factor re-ceptor（EGFR）in nasal polyps （NPs）as well as their potential roles in polyp epithelium.Methods Polyp biopsies were collected from 25 patients with NPs.Inferior turbinates were obtained from 10 subjects with septal deviation, which were served as the control group.EGF and EGFR expression levels were assessed by using immunohistochemistry and real-time quantitative PCR.Results Staining results revealed that EGF and EGFR mainly localized in basal epithe-lial cells,and their protein levels were significantly lower in NP than in the control. Down-regulation of both EGF and EGFR mRNA levels were further confirmed in NP as compared with control samples.Conclusion Lower expression of EGF and EGFR in epithelium may be involved in the defect of epithelial repair process in NP.