中文摘要：

目的探讨对感兴趣区周围施加预饱和带及静脉注入钆类对比剂是否会影响在体肾脏3．0T单体素质子磁共振波谱（MRS）的匀场与抑水效果。方法对21名肾脏临床及影像学检查未见异常的受检者，使用GE Signa ExciteHD3．0T超导MR扫描仪，8通道相控阵线圈采集肾脏单体素PRESS序列波谱。保持感兴趣区位置不变，在静脉注射Gd—DT—PA前后感兴趣区周围分别施加及不施加预饱和带行MRS自动预扫描程序。结果①非增强施加预饱和带组较非增强未施加预饱和带组匀场效果（Z=-2．801，P=0．005）和水抑制效果（Z=-2．880，P=0．004）均变好。②增强施加预饱和带组较增强未施加预饱和带组匀场效果（Z=-4．434，P〈0．0001）和水抑制效果（Z=-4．709，P〈0．0001）均变好。③施加预饱和带组静脉注入钆类对比剂后较非增强时匀场（Z=-4．785，P〈0．0001）和抑水（Z=-4．788，P〈0．0001）均变差。结论感兴趣区周围施加预饱和带在静脉注入钆类对比剂前后均有利于获得有效地匀场和水抑制。肾脏实质MRS匀场和抑水受静脉注入钆类对比剂的影响，推荐施加预饱和带后、注入Gd—DTPA对比剂前行波谱采集。

英文摘要：

Objective To evaluate the effect of intravenous Gd-DTPA and saturated zone on kidney proton MRS water suppression and shimming. Methods Twenty-one subjects with normal kidney was enrolled. Proton MRS was performed with a GE Signa Excite HD 3.0T system and eight-channel phased-array coils using PRESS sequence. MRS prescan was performed before and aher intravenous Gd DTPA with and without saturated zone, respectively. Results Before administration of contrast medium, saturated zone was helpful for effective shimming （Z=-2. 801, P=0. 005） and water suppression （Z=-2. 880, P=0. 004）. After administration of contrast medium, saturated zone was also helpful for effective shimming （Z= -4. 434, P〈0. 0001） and water suppression （Z=-4. 709, P〈0. 0001）. Before and after administration of contrast medium, water suppression （Z=-4. 788, P〈0. 0001） and shimming （Z= -4,785, P〈0. 0001） of kidney was poor. Conclusion It is better to acquire MRS data before administration of contrast medium in kidney with saturated zone. Intravenous Gd-DTPA has effect on kidney proton MRS water suppression and shimming, thus MRS should be acquired after saturated zone but before administration of contrast medium.