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中文摘要：
通过研究芫花与甘草合煎液中化学成分相互作用及其变化特点,揭示其＂反＂的可能特征与机制。以中药＂十八反＂中芫花/醋芫花-甘草多个不同配比组合为研究对象,采用超高效液相色谱串联四级杆飞行时间质谱（UPLC-Q-TOF/MS）及超高效液相色谱串联三重四级杆质谱（UPLC-TQ/MS）联用集成技术,分析其化学成分相互作用及其变化特点。结果表明,芫花/醋芫花-甘草不同配比合煎对其中化学物质的溶出具有一定的规律性,芫花不论醋炙与否,与甘草合煎时,随甘草比例升高,芫花中二萜类等毒性成分溶出明显提高,尤其对芫花酯甲、芫花酯乙及芫花酯已的溶出影响最为显著。从反药合煎过程化学物质相互作用促使毒性成分的溶出释放增加导致配伍禁忌的角度,揭示了甘草所含化学成分促使芫花中二萜类等毒性物质的溶出释放增加是芫花与甘草配伍禁忌的物质基础和可能机制之一。
英文摘要：
By investigating the interaction between components from Flos Genkwa（FG） and Radix et Rhizoma Glycyrrhizae（RRG） and the dissolution profile of toxic components in co-decoction,the characteristics and possible mechanism of incompatibility were revealed.Ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry（UPLC-Q-TOF/MS） and ultra-high performance liquid chromatography triple-quadrupole mass spectrometry（UPLC-TQ/MS） were used to analyze multi-components in different herb extractions prepared by different ratios of FG/FG processed by vinegar（FGV） and RRG,which reflect the interaction and characteristics of multiple components in incompatibility combinations.The results showed that the components dissolution was influenced by compatibility ratio with certain regularity.Whether FG processed by vinegar or not,with the increase of RRG in co-decoction,the dissolution of diterpenes,especially for yuanhuacine,yuanhuadine and yuanhuajine,the toxic ingredients of FG,increased significantly.From these results,the material basis and one possible mechanism of incompatibility between FG and RRG is the increasing dissolution of diterpenes,toxic components of FG in co-decoction process,which caused by interaction between multi-components in these two herbs.
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