中文摘要：

目的 分析异基因造血干细胞移植（allo-HSCT）后迟发性非感染性肺部并发症（LONIPC）的发生和危险因素.方法 回顾性分析我院2003年1月至2006年8月144例接受allo-HSCT并存活超过3个月的患者资料,统计LONIPC的发生率,分析其发生的危险因素.结果 144例患者中位随访时间为1149（103～2151）d,其中24例（16.7%）被诊断为LONIPC,发病中位时间为allo-HSCT后235（116～950）d.单因素分析结果显示,LONIPC的发生与巨细胞病毒（CMV）抗原血症（P＝0.000）、急性移植物抗宿主病（aGVHD）（P=0.026）、慢性移植物抗宿主病（cGVHD）（P=0.002）显著相关.多因素二分类Logistic回归分析结果显示,LONIPC发生的危险因素为cGVHD（OR=18.804,P=0.004）和CMV抗原血症（OR=14.376,P=0.000）.结论 LONIPC是allo-HSCT晚期主要的并发症之一,eGVHD和CMV抗原血症是allo-HSCT后LONIPC发生的相关危险因素.

英文摘要：

Abstract：Objective To analyze the incidence and the risk factors of late-onset non-infectious pulmonary complications （ LONIPC） after allogeneic hematopoietic stem cell transplantation （ allo-HSCT）.Methods Clinical data from 144 patients who underwent allo-HSCT and survived more than 3 months at our institution between January 2003 and August 2006 were collected, and the incidence and its risk factors of LONIPC were reviewed retrospectively.Results With a median follow-up time of 1149 （103 -2151） d, 24 patients （16.7% ） fulfilled the diagnostic criteria for LONIPC.The median time to diagnosis of LONIPC was 235 days after transplantation （range, 116 -950 days）.Three variables were associated with LONIPC on uni-variate analysis; CMV antigenaemia （P = 0.000） ,grade Ⅱ - Ⅳ aGVHD （P=0.026） and cGVHD （P = 0.002）.By using a Binary Logistic regression model for multivariate analysis, cGVHD（ OR = 18.804,P = 0.004） and CMV antigenaemia （ OR = 14.376,P =0.000） were the risk factors of LONIPC.Conclusion LONIPC is one of the major complications after allo-HSCT and cGVHD and CMV antigenaemia are the risk factors for developing LONIPC.